PEER-REVIEWED ARTICLES, ACADEMIC BOOK CHAPTERS, CONFERENCE PROCEEDINGS, PATENTS, and PATENT APPLICATIONS

 

PEER-REVIEWED ARTICLES

 

  1. Miller, M., Klyosov, A.A., Platt, D., Mayo, K. Using Pulse Field Gradient NMR diffusion measurements to define molecular weight distributions in glycan preparations. Carbohydrate Research, 344, 1205-1212 (2009)

 

  1. Miller, M., Nesmelova, I.V., Platt, D., Klyosov, A.A., Mayo, K. The carbohydrate-binding domain on galectin-1 is more extensive for a complex glycan than for simple saccharides: implications for galectin-glycan interactions at the cell surface. Biochem. J. 421, 211-221 (2009).

 

  1. Miller, M.C., Klyosov, A., Mayo, K.H. The α-galactomannan Davanat binds galectin-1 at a site different from the conventional galectin carbohydrate binding domain. Glycobiology, 19, No. 9, 1034-1045 (2009).
  1. Tevyashova, A.N., Olsufyeva, E.N., Preobrazhenskaya, M.N., Klyosov, A.A., Zomer, E., Platt, D. New Conjugates of an Antitumor Antibiotics Doxorubicin with a Water-soluble Galactomannan: Synthesis and Biological Activity. Bioorganic Chemistry (Moscow, in Russian), v. 33, No. 1, pp. 1 - 8 (2007)
  2. Olsufyeva, E.N., Tevyashova, A.N., Trestchalin, I.D., Preobrazhenskaya, M.N., Platt, D., Klyosov, A.A. Synthesis and Antitumor Activity of New Galactose-Containing Derivatives of Doxorubicin. Carbohydrate Research, 338 (13), 1359-1367, 2003.
  3. Klyosov, A.A., Platt, D., Zomer, E. Preclinical Studies of Anticancer Efficacy of 5-Fluorouracil when Co-Administered with the 1,4-beta-D-Galactomannan. PRECLINICA, 1, 175-186, 2003.
  4. Miller, M.C., Ribeiro, J.P., Roldos, V., Martin-Santamaria, S., Canada, F.J., Nesmelova, I., Andre, S., Pang, M., Klyosov, A., Baum, L.G., Jimenez-Barbero, J., Gabius, H.-J., Mayo, K.H. Structural aspects of binding of alpha-linked digalactosides to human galectin-1. Glycobiology, 2011, June 28, publ. ahead of print, PMID: 21712397.

    8.   Miller, M.C., Klyosov, A.A., Mayo, K. H. The optimal structural signature for α-galactomannan binding to galectin-1. Glycobiology (in the press), 2011.

 

 

ACADEMIC BOOK CHAPTERS

In: GALECTINS (ed. Anatole Klyosov, Zbigniew Witczak, David Platt), John Wiley & Sons, 2008

    9.         Klyosov, A.A. Galectins and their functions in plain language. In: Galectins (ed. Anatole Klyosov, Zbigniew Witczak, David Platt), John Wiley & Sons, 2008, pp. 9-31.

In: CARBOHYDRATE DRUG DESIGN (ed. Anatole Klyosov, Zbigniew Witczak, David Platt), Oxford University Press, 2006

    10.          Klyosov, A.A. Carbohydrates and Drug Design. In: Carbohydrate Drug Design (Anatole A. Klyosov, Zbigniew J. Witczak, and David Platt, eds.), ACS Symposium  Series 932, American Chemical Society, Washington, DC, 2006, pp. 2 - 24.

    11.          Platt, D., Klyosov, A.A., Zomer, E. Development of a Polysaccharide as a Vehicle to Improve the Efficacy of Chemotherapeutics. In: Carbohydrate Drug Design (Anatole A.  Klyosov, Zbigniew J. Witczak, and David Platt, eds.), ACS Symposium Series 932, American Chemical Society, Washington, DC, 2006, pp. 49 - 66.

    12.          Klyosov, A.A., Zomer, E., Platt, D. DAVANAT and Colon Cancer: Preclinical and Clinical (Phase I) Studies. In: Carbohydrate Drug Design (Anatole A. Klyosov, Zbigniew J. Witczak, and David Platt, eds.), ACS Symposium Series 932, American Chemical Society, Washington, DC, 2006, pp. 67 - 104.

    13.          Klyosov, A.A., Tevyashova, A.N., Olsufyeva, E.N., Preobrazhenskaya, M.N., Zomer, E., Platt, D. Synthesis and Biological Activity of Doxo-Galactose and Doxo-Galactomannan, New Conjugates of Doxorubicin with D-Galactose and 1,4-beta-D-Galactomannan. In: Carbohydrate Drug Design (Anatole A. Klyosov, Zbigniew J. Witczak, and David Platt, eds.), ACS Symposium Series 932, American Chemical Society, Washington, DC, 2006, pp. 105 - 130.

 

CONFERENCE PROCEEDINGS

   14.         Zalupski, M., Fuloria, J., Perez, R., Abubaker, Y., Nahum, K.D., Platt, D., Klyosov, A.A. Zomer, E. Pharmacokinetic translational study in advanced solid tumors of 5-FU with an admixture of a galactomannans derivative. In: Cancer Research, Tumor Markers, Clinical Oncology. The 35th Meeting of the International Society for Oncodevelopmental Biology and Medicine, ISOBM 2007. Tumor Biology. Abstract P6_4, p. 119. Karger (Basel-Freiburg-Paris-London-New York-Bangalore-Singapore-Tokyo-Sydney). 

   15.          Demotte, N., Wieers, G., Klyosov, A., van der Bruggen, P. Is it possible to correct the impaired function of human tumor-infiltrating lymphocytes? Keystone Symposium on Molecular and Cellular Biology. New Frontiers at the Interface of Immunity and Glycobiology, March 6-11, 2011. Lake Louise, AB, Canada. Abstract 23F11.

 

US and INTERNATIONAL PATENTS GRANTED

     16.        Klyosov, A., Platt, D. Methods and Compositions for Reducing Side Effects in Chemotherapeutic Treatments. US Patent No. 6,642,205, November 4, 2003.

      17.       Klyosov, A., Platt, D. Delivery of a Therapeutic Agent in a Formulation for Reduced Toxicity. US Patent No. 6,645,946, November 11, 2003.

      18        Klyosov, A., Platt, D. Delivery of a Therapeutic Agent in a Formulation for Reduced Toxicity. US Patent No. 6,914,055, July 5, 2005.

      19.       Klyosov, A., Platt, D. Delivery of a Therapeutic Agent in a Formulation for Reduced Toxicity. US Patent No. 6,982,255, January 3, 2006.

      20.       Klyosov, A., Platt, D. Co-administration of a Polysaccharide with a Chemotherapeutic Agent for the Treatment of Cancer. US Patent No. 7,012,068, March 14, 2006.

      21.        Platt, D., Klyosov, A. Selectively Depolymerized Galactomannan Polysaccharide. US Patent No. 7,893,252, February 22, 2011. http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=7893252.PN.&OS=PN/7893252&RS=PN/7893252

      22.        Platt, D.,, Klyosov, A. Co-administration of Polysaccharide with a Chemotherapeutic Agent for the Treatment of Cancer. Patent of Australia 272022B2, February 17, 2011. Terms of the Patent: 20 years from 7 September 2004.

      23.       Klyosov, A., Platt, D. Co-administration of Polysaccharide with a Chemotherapeutic Agent for the Treatment of Cancer. Patent of Japan, No. 4744782, May 20, 2011,

 

US PATENT APPLICATIONS

 

      24.   Klyosov, A. Methods for reducing the incidence of chemotherapy-induced mucositis. PCT/US2009/053115, filed August 7, 2009.

      25.    Klyosov, A. Compounds, formulations and methods for reducing mucositis and/or other galectin-dependent pathologies. Provisional 61/332,242, filed May 7, 2010.

      26.    Platt, D., Zomer, E., Klyosov, A. Galactose-Pronged Polysaccharides in a Formulation for Antifibrotic Therapies. US Patent Application Publication, 20080107622, Published May 8, 2008.

 

      27.     Platt, D., Klyosov, A.A., Zomer, E. Co-Administration of a Polysaccharide with a Chemotherapeutic Agent for the Treatment of Cancer. US Patent Application Publication, 20080207516, published August 28, 2008.

http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220080207516%22.PGNR.&OS=DN/20080207516&RS=DN/20080207516

     28.      Platt, D., Zomer, E., Compositions and Methods for the Enhancement of Chemotherapy with Microbial Cytotoxins.  U.S. Patent Application Publication 2008-286251, published November 20, 2008 http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=8&f=G&l=50&co1=AND&d=PG01&s1=Klyosov&OS=Klyosov&RS=Klyosov

     29.       Platt, D., Klyosov, A.,A., Zomer, E. Compositions and methods for targeting metastatic tumors using multivalent ligand-linked carbohydrate polymers. Published August 28, 2008. http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=15&f=G&l=50&co1=AND&d=PG01&s1=Klyosov&OS=Klyosov&RS=Klyosov

    30.        Klyosov, A.A., Traber, P.G. Galectin Binding and Blocking Polysaccharides. Provisional 61/439,800, filed February 4, 2011.  

 

    31.       Klyosov, A.A., Traber, P.G. Methods of Treatment of Ischemic Disease  and/or Chronic Cardiovascular Disease with Galectin Binding Agents.

    32.       Platt, D., Klyosov, A.A. Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer. 12/962,296, filed August 9, 2003.

    33.       Traber, P.G., Zomer E., Klyosov, A.A. Methods of Treatment for Non-Alcoholic Steatohepatitis (NASH). Provisional U.S. Patent Application, filed September 16, 2011.

    34.        Klyosov, A.A. The Optimal Structural Signature for α-Galactomannan binding to Galectin-1. Provisional U.S. Patent Application, filed September 13, 2011.  

 

INTERNATIONAL PATENT APPLICATIONS

 

35. Klyosov, A.A., Platt, D. Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer. EPO 10184166.6

36. Platt, D., Klyosov, A. Co-administration of polysaccharide with a chemotherapeutic agent for the treatment of cancer. Australian Patent Application No. 2010257400. Austr. Ref. 19435PRO/BMN/tap, PRW ref. 89918.020603

37. Platt, D., Klyosov, A. Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer. Israel 174121, filed September 8, 2003.

38. Klyosov, A.A., Platt, D. Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of a cancer. Japanese Patent Application No. 2002-574987, Y/R: 089919.02180; O/R: IP2003-149/KI (Our Ref. 089918.021804)  

39. Platt, D., Zomer, E., Klyosov, A. Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer. Brazil PI0413410-0, filing September 8, 2003.

40. Platt, D., Zomer, E., Klyosov, A.A. Compositions and Methods for Treating Metastatic Tumors Using Multivalent Ligand-Linked Carbohydrate Polymers.  JP 2007-504160

41. European Patent Application No. 02731178.6, EPO Ref.: RJS\JWK\19462-5EP(PCT); Our Ref. 89918.021803.

42. Methods for Reducing the Incidence of Chemotherapy-Induced Mucositis. PCT/US09/053115.

43. European Patent Application No. 10184166.6, EPO Ref.: RJS\JWK\19462-5EP-DIV; Our Ref. 89918.021803.